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. 2016 Dec 21;8(12):337. doi: 10.3390/v8120337

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Human α-defensin HD5 residues critical for adenovirus neutralization. (A) Heat map of the effect of alanine substitutions on the IC50 of HD5 against a variant of HAdV-C5 (AdV5.eGFP), human papillomavirus 16 (HPV16), and anthrax lethal factor (LF), or on the LD50 of HD5 against E. coli and S. aureus according to the color key below; (B) Two views (front and back) of the HD5 dimer shown in a surface rendering. Residues are colored according to the heat map data in panel A for AdV5.eGFP. Reprinted with permission from [81].