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. 2016 Dec 1;7(12):112. doi: 10.3390/genes7120112

Figure 3.

Figure 3

Temperature- and protein-dependent mechanisms of counter-silencing in Shigella. (A) At 30 °C, the virF promoter is silenced through H-NS-mediated bridging of two discrete binding regions separated by a region of DNA curvature. As the temperature increases to 37 °C, movement of the curvature remodels the H-NS bridging complex leading to virF expression [40,55]; (B) H-NS directly silences the icsB promoter. VirB binds DNA, induces a local DNA bend and oligomerizes along the DNA, which destabilizes the downstream H-NS silencing complex [56].