Table 1.
Genes that have been associated with primary ovarian insufficiency (POI). Adopted and modified from Qin et al. [15].
| Gene | Localization |
|---|---|
| BMP15—Bone morphogenetic protein 15 | Xp11.22 |
| AR—Androgen receptor | Xq12 |
| FOXO4—Forkhead box O4 | Xq13.1 |
| POF1B—Premature ovarian failure, 1B | Xq21.2 |
| DACH2—Dachshund family transcription factor 2 | Xq21.3 |
| PGRMC1—Progesterone receptor membrane component 1 | Xq22-q24 |
| FMR1—Fragile X mental retardation 1 | Xq27.3 |
| FMR2—Fragile X mental retardation 2 | Xq28 |
| FIGLA—Folliculogenesis specific bHLH transcription factor | 2p13.3 |
| LHR—Luteinizing hormone receptor | 2p21 |
| FSHR—Follicle-stimulating hormone receptor | 2p21-p16 |
| INHA—Inhibin A | 2q35 |
| GDF9—Growth differentiation factor 9 | 5q31.1 |
| FOXO3a—Forkhead box O3 | 6q21 |
| NOBOX—Newborn ovary homeobox gene | 7q35 |
| STAG3—Stromal Antigen 3 | 7q22.1 |
| AMHR2—Anti-Mullerian hormone receptor, type II | 12q13 |
| FOXO1—Forkhead box O1 | 13q14.1 |
| SPO11—Meiotic protein covalently bound to DSB | 20q13.31 |
| DMC1—DNA meiotic recombinase 1 | 22q13.1 |