Table 2.

Functional involvement of the differentially expressed miRs in immune cells.

Gene Name	Regulation	Immune Compartment	Functions in Immune System	Reference
miR-574-5p	↑	myeloid	promotes differentiation in monocytes	[15]
miR-1246	↑	T lymphocytes	upregulated in Tregs	[16]
miR-424-3p	↑	myeloid	involved in monocyte differentiation	[17,18]
miR-584-5p	↑	myeloid	regulated in AML CD34+ cell line	[19]
miR-214-3p	↓	T lymphocytes	upregulated in stimulated T cells and Tregs	[20,21]
miR-199a-3p	↓	myeloid	involved in leukemogenesis	[22]
miR-130a-3p	↓	T lymphocytes	upregulated in CD8 T cells inhibits CD69	[23]
miR-195-5p	↓	myeloid	regulated in monocytes	[24]
miR-30c-5p	↓	myeloid	regulated in mDCs and pDCs	[25]
let-7c-5p	↓	myeloid	promotes M2 polarization	[26,27]
miR-23a-3p	↓	T lymphocytes; myeloid	represses CTL activity; regulated in mDCs	[25,28]
miR-99a-5p	↓	B lymphocytes	involved in B cell differentiation	[29]
miR-199a-5p	↓	T lymphocytes	overexpressed in T cells vs ALCL ALK+	[30]
miR-126-3p	↓	T lymphocytes	downregulated in activated T cells	[31]
miR-193b-3p	↓	T lymphocytes	involved in T cell maturation	[32]
let-7e-5p	↓	myeloid	regulated in macrophage upon TLR4	[33]
miR-365a-3p	↓	T lymphocytes	upregulated in T activation	[31]
miR-10b-5p	↓	myeloid	upregulated in CD34+ in myelofibrosis	[34]
miR-139-5p	↓	T lymphocytes	regulated in CTLs	[35]

Expression pattern in SNB from patients with progressing disease: ↑, increased expression; ↓, decreased expression. Tregs: regulatory T lymphocytes; AML: acute myeloid leukemia; mDCs: monocyte-derived dendritic cells; pDCs: plasmacytoid dendritic cells; CTLs: cytotoxic T lymphocytes; ALCL: anaplastic large cell lymphoma; ALK: anaplastic lymphoma kinase; MDSCs: myeloid-derived suppressor cells; TLR4: Toll-like receptor 4.