Table 6.

Past studies exploring antichlamydial properties of polyherbal formulations.

Antimicrobial Agent	Chlamydial Species	Study Design	Effects	References
Praneem: S. mukerossi saponins, A. indica seed extract, Quinine hydrochloride	C. trachomatis (D)	In vivo Pre-inoculation: one dose administered prior to inoculation. (mice) Clinical treatment: administered daily for 7 days. (human)	Application of 5 mL of cream for 8 days, resulted in C. trachomatis being cleared from the cervicovaginal region of patients. Topical application is effective in blocking chlamydial vaginal transmission, with a transmission rate of only ~14%. Toxicity studies indicate a lack of side effects, such as skin irritation or sensitization.	[90,91,92]
CH-005: S. mukerossi saponins, M. citrata oil, Natural polycationic polymer	C. trachomatis (D)	In vivo Pre-inoculation: one dose administered prior to inoculation. (mice)	Topical application is effective in blocking chlamydial vaginal transmission with a transmission rate of only ~4%.	[91]
BASANT: S. mukerossi saponins, A. vera, P. emblica, curcumin	C. trachomatis (D)	In vitro Pre-treatment: incubated with EBs for 15, 30, or 60 min prior to inoculation. Post-inoculation: administered at 2 h p.i.	In vitro pre-incubation exposure, 100% inhibition was achieved in 15 min at 65 μg/mL, 30 min at 35 μg/mL, and 60 min at 15 μg/mL. In vitro post-incubation exposure, the MIC was determined to be ~9 μg/mL. There are no known side effects of BASANT, which is equally effective as a cream or tablet.	[93,94]