Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 10;4(4):47. doi: 10.3390/microorganisms4040047

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Immunity to Fungal Infections. Fungal infection (1) stimulates the arrival of monocytes at the site of infection (2), which subsequently mature into monocyte-derived dendritic cells (moDCs). Depending on local environmental host and pathogen factors, these moDCs can develop into either inflammatory DCs (inf-DCs; 3a) or immunomodulatory DCs (imo-DCs; 3b), which subsequently direct the immune response. Inf-DCs promote sterilizing immunity characterized by interferon gamma (IFNγ)-producing Th1 cells, interleukin (IL)-17-producing Th17 cells, and “classically activated” exudate macrophages (ExMs; 4a). Imo-DCs promote fungal persistence characterized by IL-10-producing Treg cells, IL-4-, IL-5, and IL-13-producing Th2 cells, and “alternatively-activated” exudate macrophages (4b).