. 2016 Sep 7;2(4):385–391. doi: 10.1002/osp4.62

Table 1.

Fat‐free mass expressed as grams or percent of body weight of DIO rats at baseline (cohort 1; after prolonged high‐fat diet feeding), after CR to induce 11% (cohort 2) or 25% (cohort 3) body weight loss and at termination after 28 days of vehicle or drug treatment

Cohort	Treatment	Baseline fat‐free mass (g)	Post‐CR fat‐free mass (g)	Terminal fat‐free mass (g)	Baseline fat‐free mass (%)	Post‐CR fat‐free mass (%)	Terminal fat‐free mass (%)	Total food intake (g)
Cohort 1	Vehicle	441 ± 17	—	410 ± 13	64.1 ± 3.5	—	60.7 ± 3.2	464 ± 15
	Amylin	423 ± 14	—	385 ± 11	63.7 ± 1.7	—	63.6 ± 1.6	336 ± 23^‡^,^§
	Leptin	437 ± 8	—	396 ± 8	63.0 ± 1.7	—	58.0 ± 1.9	466 ± 12
	Amylin/leptin	451 ± 16	—	403 ± 12	62.5 ± 2.0	—	61.5 ± 2.3	369 ± 20^‡^,^§
Cohort 2	Vehicle	443 ± 20	391 ± 15^*	416 ± 17^*^,^†	64.3 ± 2.6	64.0 ± 2.6	62.1 ± 2.2	538 ± 19
	Amylin	455 ± 19	402 ± 16^*	408 ± 19^*	64.1 ± 0.6	64.3 ± 0.8	64.6 ± 0.4	442 ± 16^‡^,^§
	Leptin	458 ± 30	397 ± 19^*	416 ± 22^*	65.2 ± 1.9	65.0 ± 1.8	63.3 ± 0.9	550 ± 21^‡
	Amylin/leptin	455 ± 13	395 ± 9^*	402 ± 13^*	65.1 ± 2.8	64.9 ± 2.6	66.0 ± 2.7	438 ± 23^‡^,^§
Cohort 3	Vehicle	459 ± 13	369 ± 15^*	418 ± 15^*^,^†	66.3 ± 3.6	72.0 ± 2.8^*	64.5 ± 3.1^†	692 ± 55
	Amylin	443 ± 16	354 ± 12^*	396 ± 21^*^,^†	64.3 ± 2.4	68.7 ± 1.5^*	68.1 ± 1.0^*	486 ± 33^‡^,^§
	Leptin	452 ± 24	379 ± 16^*	416 ± 21^*^,^†	65.7 ± 1.8	73.1 ± 1.3^*	64.5 ± 1.8^†	645 ± 32
	Amylin/leptin	426 ± 6	352 ± 8^*	384 ± 8^*^,^†	62.1 ± 0.6	67.7 ± 0.6^*	66.3 ± 1.0^*	508 ± 23^‡

Total cumulative food intake is also shown for the 28‐day treatment period.

p < 0.05 vs. baseline.

^†

p < 0.05 vs. post‐CR within treatment group.

^‡

p < 0.05 vs. vehicle.

^§

p < 0.05 vs. leptin within cohort.

CR, calorie restriction; DIO, diet‐induced obese.