Table 1.
Comparison of the characteristics of the controls and study patients with biopsy proven
| Biopsy-proven ALD | Biopsy-proven NAFLD | Clinically diagnosed NAFLD | Controls | P value | |
| (n = 14) | (n = 9) | (n = 16) | (n = 10) | Biopsy-proven ALD vs NAFLD | |
| Age (yr) | 53 (45-60) | 54 (49-66) | 49 (43-54) | 51 (39-60) | NS |
| Gender (male:female) | 11:3 | 6:3 | 16:0 | 10:0 | NS |
| AST (U/L) | 74 (41-105) | 45 (38-95) | 32 (24-42) | 19 (15-21) | NS |
| ALT (U/L) | 19 (13-22) | 35 (27-67) | 48 (35-74.5) | 18 (14-20) | 0.0166 |
| Albumin (g/dL) | 4.1 (3.2-4.4) | 4.6 (4.1-4.7) | 4.4 (4.3-4.6) | 4.6 (4.3-4.8) | NS |
| Total bilirubin (mg/dL) | 1 (0.6-3.1) | 0.7 (0.6-0.8) | 0.8 (0.6-0.9) | 0.9 (0.6-1.2) | NS |
| Triglyceride (mg/dL) | 186 (99-284) | 184 (101-298) | 187 (102-212) | 130 (111-139) | NS |
| HDL-cholesterol (mg/dL) | 40 (30-56) | 43 (29-52) | 42 (39-54) | 50 (42-56) | NS |
| LDL -cholesterol (mg/dL) | 75 (43-105) | 116 (97-153) | 122 (98-157) | 113 (101-136) | 0.0181 |
| GGT (U/L) | 368 (296-421) | 94 (62-170) | 74 (57-112) | 24 (19-42) | 0.0018 |
| b/t-GGT ratio | 0.1 (0.07-0.13) | 0.16 (0.13-0.26) | 0.18 (0.14-0.24) | 0.12 (0.08-0.15) | NS |
| m/t-GGT ratio | 0.04 (0.02-0.05) | 0.04 (0.02-0.05) | 0.04 (0.03-0.05) | 0.02 (0.02-0.03) | NS |
| s/t-GGT ratio | 0.78 (0.65-0.80) | 0.55 (0.49-0.64) | 0.54 (0.49-0.60) | 0.4 (0.31-0.44) | 0.0158 |
| f/t-GGT ratio | 0.12 (0.08-0.15) | 0.18 (0.15-0.26) | 0.23 (0.15-0.29) | 0.45 (0.37-0.63) | 0.0055 |
| b/s-GGT ratio | 0.14 (0.09-0.20) | 0.33 (0.21-0.53) | 0.35 (0.24-0.51) | 0.29 (0.19-0.52) | 0.0456 |
| s/f-GGT ratio | 6.68 (3.67-10.58) | 3.1 (2.18-4.32) | 2.09 (1.69-3.98) | 0.96 (0.48-1.11) | 0.0086 |
Data are presented as median (25th-75th percentile). Statistical analysis: Wilcoxon-Mann-Whitney U test. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyltransferase; ALD: Alcoholic liver disease; NAFLD: Non-alcoholic fatty liver disease; NS: Not significant; HDL: High density lipoprotein; LDL: Low density lipoprotein; b-GGT: Big-GGT; m-GGT: Medium-GGT; s-GGT: Small-GGT; f-GGT: Free-GGT.