Table 4.
Multivariate prognostic analyses of anatomic factors in the 749 patients with NPC
| Variable | Disease failure | Local failure | Distant failure | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (>50 vs. ≤50 years) | 1.857 (1.365–2.516) | <0.001 | 0.996 (0.476–2.080) | 0.997 | 1.433 (0.967–2.120) | 0.074 |
| Histological type (WHO II/III vs. WHO I) | 1.371 (0.829–2.264) | 0.221 | 0.843 (0.327–2.125) | 0.710 | 3.614 (1.804–7.219) | <0.001 |
| Chemotherapy (CCRT, induction with CCRT, and CCRT with adjuvant vs. none) | 1.207 (0.794–1.843) | 0.383 | 0.624 (0.273–1.410) | 0.269 | 1.459 (0.834–2.569) | 0.190 |
| Nasal cavity involvement (yes vs. no) | 0.946 (0.683–1.311) | 0.741 | 0.867 (0.429–1.752) | 0.690 | 0.818 (0.547–1.225) | 0.330 |
| Oropharyngeal involvement (yes vs. no) | 1.208 (0.812–1.798) | 0.431 (0.130–1.432) | 0.169 | 1.491 (0.941–2.362) | 0.089 | |
| Parapharyngeal involvement (yes vs. no) | 1.843 (1.144–2.969) | 0.011 | 2.212 (0.690–7.141) | 0.172 | 2.040 (1.115–3.764) | 0.017 |
| Skull base involvement (yes vs. no) | 1.273 (0.851–1.906) | 0.240 | 2.113 (0.790–5.651) | 0.136 | 1.248 (0.759–2.052) | 0.383 |
| Paranasal sinus involvement (yes vs. no) | 1.078 (0.704–1.650) | 0.729 | 1.246 (0.526–2.949) | 0.617 | 0.937 (0.543–1.616) | 0.815 |
| Cranial nerve involvement (yes vs. no) | 1.394 (0.867–2.178) | 0.139 | 2.012 (0.833–4.881) | 0.120 | 1.247 (0.703–2.218) | 0.399 |
| Intracranial involvement (yes vs. no) | 1.303 (0.871–1.950) | 0.198 | 1.119 (0.468–2.674) | 0.800 | 1.538 (1.056–2.490) | 0.040 |
| Infratemporal fossa involvement (yes vs. no) | 1.035 (0.564–1.875) | 0.893 | 0.616 (0.175–2.137) | 0.458 | 0.737 (0.320–1.675) | 0.467 |
| Orbit involvement (yes vs. no) | 1.641 (0.914–2.937) | 0.109 | 4.067 (1.369–12.103) | 0.011 | 1.537 (0.733–3.231) | 0.251 |
| Retropharyngeal lymph node involvement (yes vs. no) | 1.583 (1.102–2.273) | 0.011 | 1.519 (0.679–3.406) | 0.309 | 1.565 (1.078–2.499) | 0.030 |
| Cervical lymph node involvement | ||||||
| Longest diameter (>6 cm vs. ≤6 cm) | 2.829 (1.603–4.991) | <0.001 | 0.815 (0.107–6.219) | 0.840 | 3.050 (1.625–5.727) | 0.001 |
| Laterality (bilateral vs. unilateral) | 1.475 (1.031–2.107) | 0.032 | 0.398 (0.672–6.513) | 0.423 | 1.625 (1.078–2.453) | 0.019 |
| Ho’s location (Ho’s vs. above Ho’s) | 2.396 (1.435–3.996) | 0.001 | 0.567 (0.073–4.272) | 0.583 | 2.859 (1.617–5.061) | <0.001 |
HR hazard ratio, CI confidence interval, CCRT current chemoradiotherapy