Figure 4.

Pulldown efficiency among segments with a given number of CpGs. The curve marked “All separations” includes all segments that contain the number of CpGs selected for, while the curve marked “Well-separated CpGs” only includes the subset of segments where each CpG is separated by at least 3 bp from any other. For 2≤ CpG number ≤7, a t-test comparison of 20 sub-binned pulldown efficiency calculations shows that the difference between the pulldown efficiencies is statistically significant. We also see that pulldown efficiency increases nonlinearly with CpG number, until the effect saturates at 5 mCpG. To see this figure in color, go online.