Figure 1.

Replacement of tyrosine with glutamate in IDO1 ITIMs. (A) MEP analysis of l‐Tyr, l‐pTyr and l‐Glu. Red and blue coloured surfaces indicate electrostatic negative and positive potential regions respectively. (B) Peptide sequence alignment encoded by murine Ido1 and its mutated forms as deduced by gene sequencing. Stars indicate residues identical to the WT sequence (NCBI Reference Sequence: NP_032350.1). ITIM1 and ITIM2 consensus sequences are shown in the inset and bold letters indicate the amino acid substitution.