Figure 2.

The roles of nucleus PRDX1 in the H₂O₂‐induced apoptosis. It is also known that PRDX1 functions as a chaperone in the form of oligomers, and molecular chaperone activities enhanced under oxidative stress conditions. PRDX1 oligomer directly interacts with the transcription factors including c‐Myc, NF‐κB and AR, and thus affects their bioactivities upon gene regulation, which in turn induces or suppresses cell death. In addition, p53 induces the expression of apoptosis factors such as Bak and Bax under oxidative stress conditions, and promotes the activation of caspases and p53‐dependent mitochondria apoptotic signalling pathway. Importantly, PRDX1 oligomer is an essential intermediate in H₂O₂‐induced activation of c‐Abl/MST1/FOXO signalling pathway and cell apoptosis through direct interaction with p53. Furthermore, it has been recognized that c‐Abl acts as a modulator of p53. PRDX1^oli, PRDX1 oligomer.