Figure 2.

Responses of low threshold stretch‐sensitive and high threshold afferents to low concentration of H₂O₂ and capsaicin. (A) The shape of seven superimposed action potentials for each of the three discriminated units from tracing in B: unit 1 – low threshold stretch‐sensitive afferent; unit 2 and unit 3 – high threshold afferents. (B) Typical traces showing bursting firing of high threshold afferents (unit 2 and unit 3) evoked by H₂O₂ (300 μM) and capsaicin (3 μM) but not low threshold stretch‐sensitive afferent (unit 1). Note that low threshold stretch‐sensitive afferent, but not high threshold afferents, was strongly activated by stretch with 400 mN load. (C) Concentration‐response curve for activation of high threshold afferents (n = 9, N = 6) by H₂O₂.