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Typical responses of high threshold afferents to AITC, NPPB and icilin. (A) Typical traces showing activation of high threshold afferent by the TRPA1 channel agonist, AITC (30 μM). (B) Typical traces showing activation of high threshold afferent by the TRPM8 channel agonist, icilin (5 μM). (C) and (D) – average data for concentration‐dependent activation of high threshold afferents by AITC (n = 14, N = 9) and NPPB (n = 10, N = 7) respectively.
