Figure 6.

Effects of the TRPA1 channel antagonist, HC‐030031 on H₂O₂‐induced activation of high threshold afferents. (A) Typical traces showing activation of high threshold afferents by H₂O₂ (300 μM) in control and after 30 min of application of HC‐030031 (10 μM). Insert shows the shape of seven superimposed action potentials for discriminated high threshold single unit. (B) Average data of the effects of repeated application of H₂O₂ (300 μM) on the same high threshold afferents (n = 7, N = 5). (C) Average data of the effect of HC‐030031 (10 μM) on the H₂O₂ (300 μM)‐induced activation of high threshold afferents (n = 11, N = 7). *P < 0.05, significant effect of HC‐030031.