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. 2016 Dec 20;174(2):150–162. doi: 10.1111/bph.13665

Figure 5.

Figure 5

Voltage‐dependent potassium KV currents in freshly isolated Kcnq1 −/− VSMCs. Original recordings of Kv currents in VSMCs from Kcnq1 −/− and wild‐type (WT) (Kcnq1 +/+) mice (A). Normalized peak Kv currents (B), cell capacitance (C) and relative inhibition of KV currents by 30 μM XE991 (D). Original recordings of whole‐cell KV currents in a Kcnq1 −/− VSMC in the absence (Control) and presence of 30 μM XE991 (E). Voltage clamp protocol included command voltage steps (500 ms) ranging from −100 to +60 mV in 20 mV increments. Holding potential was −60 mV; test pulse frequency was 1·20 s−1. Current–voltage (I–V) relationship of the currents from (E) (F). n = 5 per group.