Figure 1.

Fenofibrate produces antidepressant‐like effects in the FST and TST tests. C57BL/6J mice were injected i.p. with a single dose of vehicle (Control), fluoxetine (20 mg·kg⁻¹), or fenofibrate (50, 100 mg·kg⁻¹). The behavioural tests were conducted 30 min after the injection. The vehicle refers to 5% dextrose (pH 7.0) with 2.5% DMSO and 10% Cremaphor EL (i.p.). (A) Fenofibrate significantly decreased the immobility time of C57BL/6J mice in the FST test. (B) Fenofibrate significantly decreased the immobility time of C57BL/6J mice in the TST test. (C) Fenofibrate treatment produced no effects on spontaneous locomotor activity of mice in the open‐field test. The data are expressed as mean ± SEM (n = 11–12); * P < 0.05. Comparisons were made by one‐way ANOVA followed by post hoc LSD test.