Skip to main content
. 2016 Dec 9;174(2):177–194. doi: 10.1111/bph.13668

Figure 4.

Figure 4

Fenofibrate treatment reverses the CSDS‐induced decrease in the hippocampal BDNF signalling pathway. (A) Our western blotting data showed that fenofibrate treatment restored the CSDS‐induced decrease in BDNF, pERK1/2, pAkt and pCREB protein levels in the hippocampus. CSDS + fenofibrate mice displayed significantly higher expression of BDNF, pERK1/2, pAkt and pCREB in the hippocampus than in that of CSDS + vehicle mice. (B) Fenofibrate treatment could not reverse the CSDS‐induced decrease in BDNF and pCREB expression in the mPFC. (C) Fenofibrate treatment produced no effects on the CSDS‐induced enhancement of BDNF and pCREB levels in the NAc. Data are expressed as means ± SEM (n = 5); * P < 0.05; n.s., no significance. Comparisons were made by one‐way ANOVA followed by post hoc LSD test.