Table 3.
Selected models parameter estimates
| Gastric emptying model | Cholecystokinin model | Gallbladder emptying model | ||||||
|---|---|---|---|---|---|---|---|---|
|
Parameters (unit) |
Estimates (RSE%) | BSV CV% (RSE%) |
Parameters (unit) |
Estimates (RSE%) | BSV CV% (RSE%) |
Parameters (unit) |
Estimates (RSE%) | BSV CV% (RSE%) |
| CL/F (L/min) | 0.441 (2.5) | BASECCKF (pM) | 0.506 (11) | 58 (42) | BASEBILE (mL) | 36.3 (2.5) | 27 (11) | |
| Vc/F (L) | 19.5 (12) | 68 (32) | BASECCKL (pM) | 0.0882 (125) | KRB (min−1) | 0.0618 (13) | 90 (29) | |
| Vp/F (L) | 48.1 (4.4) | POOLCCKF (pM) | 17.1 (6.9) | SMAX‐BILE | 6.62 (12) | |||
| Q/F (L/min) | 1.56 (5.6) | POOLCCKL (pM) | 1.95 (11) | 42 (21) | S50‐BILE | 5.52 (20) | 80 (15) | |
| F1 | 1 fixed | 22 (12) | KoutF (min−1) | 0.355 (8.1) | 72 (25) | KDJ (min−1) | 0.0833 fixed | |
| HL‐KA [Link] (min) | 8.19 (8.6) | KoutL (min−1) | 0.00546 (21) | RAMAX | 2.292 fixed | |||
| KG0 (min−1) | 1.06 (21) | 155 (17) | SMAX‐CCKF | 0.193 (18) | KM (kcal) | 25.12 fixed | ||
| KUL (min−1) | 0.0266 (10) | 56 (21) | S50‐CCKF | 0.592 (82) | POTfatB (%) | 100 fixed | ||
| RAMAX | 2.292 fixed | SLPCCKL | 0.0377 (54) | POTprotB (%) | 67.9 (26) | |||
| KM (kcal) | 25.12 fixed | KDJ (min−1) | 0.0833 fixed | POTcarbB (%) | 2.25 (22) | |||
| SLPCAL | −0.0173 (8.8) | 19 (31) | KJI (min−1) | 0.0111 fixed | WT‐BASEBILE (%/kg) | +1.19 (13) | ||
| SIG | 0.285 (17) | RAMAX | 2.292 fixed | AGE‐S50‐BILE (%/year) | +2.15 (21) | |||
| T50OGTT (min) | 15.7 (13) | KM (kcal) | 25.12 fixed | Add. Err. (mL) | 2.33 (12) | |||
| T50Fat (min) | 23.1 (13) | POTfatC (%) | 100 fixed | Prop. Err. (%) | 7.66 (19) | |||
| SEX‐SLPCAL (%) | +40.7 (18) | POTprotC (%) | 0 fixed | |||||
| Prop. Err. (%) | 14.8 (2.3) | POTcarbC (%) | 10.1 (65) | Derived parameters b | ||||
| T2D‐POTcarbC (%) | −81.1 (6.5) | RprodB (mL/min) | 2.24 | |||||
| Prop. Err. (%) | 29.5 (32) | |||||||
| Derived parameters b | ||||||||
| RprodF (pM/min) | 0.180 | |||||||
| RprodL (pM/min) | 0.000482 | |||||||
| KRF (min−1) | 0.0105 | |||||||
| KRL (min−1) | 0.000247 | |||||||
Add. Err, additive part of the residual unexplained variability; AGE‐S50‐BILE, effect of age on S50‐BILE; BASEBILE, baseline gallbladder volume; BASECCKF, and BASECCKL, baseline plasma concentrations of CCKF and CCKL; BSV, between subject variability; CL/F, apparent acetaminophen clearance; CV, coefficient of variation; F1, relative acetaminophen bioavailability; HL‐KA, half‐life of the acetaminophen absorption rate; KDJ, nutrient transfer rate constant between duodenum and jejunum; KG0, baseline gastric emptying rate constant; KM, potency of caloric absorption; KJI, nutrient transfer rate constant between upper and lower jejunum; KoutF, KoutL, the CCKF and CCKL plasma disappearance rate constant; KRB, gallbladder emptying rate constant; KRF CCKF, pool emptying rate constant calculated as RprodF/POOLCCKF; KRL CCKL, pool emptying rate constant calculated as RprodL/POOLCCKL; KUL, nutrients transfer rate constant between upper and lower small intestine; POOLCCKF, POOLCCKL, pool size of CCKF and CCKL; POTcarbB, POTfatB, POTprotB, relative potency of carbohydrates, fats, and proteins on gallbladder emptying; POTcarbC, POTfatC, POTprotC, relative potency of carbohydrates, fats, and proteins on the release of CCK; Prop. Err., proportional part of the residual unexplained variability; Q/F, apparent acetaminophen inter‐compartmental clearance; RAMAX, maximal nutrients absorption rate; RprodB, rate of bile production calculated as BASEBILE x KRB; RprodF, rate of CCKF production calculated as BASECCKF x KoutF; RprodL, rate of CCKL production calculated as BASECCKL x KoutL; RSE, relative standard error; S50‐BILE, nutrients signal leading to 50% effect of SMAX‐BILE; S50‐CCKF, signal leading to 50% effect of SMAX‐CCKF; SEX‐SLPCAL, effect of gender on SLPCAL, SIG, sigmoidicity factor of the gastric emptying onset; SLPCAL, slope of the caloric feedback loop on gastric emptying; SLPCCKL, slope of the nutrients signal effect on release of CCKL; SMAX‐BILE, maximal gallbladder emptying effect; SMAX‐CCKF, maximal secretion effect on CCKF; T2D‐POTcarbC, effect of type 2 diabetes on POTcarbC; T50OGTT and T50Fat, time to 50% of maximal gastric emptying onset for carbohydrate and fat based test drink; VC/F and VP/F, apparent acetaminophen central and peripheral volumes of distribution; WT‐BASEBILE, effect of body weight on BASEBILE.
Parameter with prior information (HL‐KA_prior = 6.8 ± 0.9 min).
Typical parameter value not estimated but derived from other estimated parameters.