Figure 14.

(A) The SPAAC ligation was employed to combine ⁶⁴Cu–DOTA–Lys–PEG₄–DBCO prosthetic groups and azide-modified chitosan nanoparticles (CNP) to create ⁶⁴Cu-labeled CNPs. (B) MicroPET images of mice bearing SCC-7 xenografts acquired 2–50 h after the injection of the ⁶⁴Cu–CNPs (250 μCi, 200 μg per mouse) reveal tumoral activity concentrations of up to 11.3 ± 1.3% ID/g at 50 h post-injection. Reprinted with permission from Lee et al., copyright 2013 American Chemical Society.