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Expression and biogenesis of eukaryotic box C/D and box H/ACA RNPs. Key expression and biogenesis pathways and components are indicated. Mammalian box C/D and H/ACA RNAs are largely encoded as introns of functional genes. ‘E’ denotes ‘exon’ and ‘BP’ denotes the splicing branch point. Cajal body is the site of spliceosomal RNA modifications and nucleolus is the site of ribosomal RNA modifications. ‘m’ indicates 2′-O-methylation and ‘Ψ’ indicates pseudouridylation.
