Fig. 6.

Emergence and progression of glioma were delayed upon treatment with the investigational drug etomoxir. Mouse 077 (control) and mouse 078 (etomoxir) were subjected to MRI to track tumor progression during the study. Coronal images throughout the brain are shown for Mouse 077 across the entire experimental time-course (A-E). At 46 days post cell implantation (DPI), an injection track was observed with no evidence of tumor (A). At 53 DPI, there was no evidence of tumor and no clinical symptoms (B). At 67 DPI, a 1.0 mm tumor was observed with no clinical symptoms (C). At 72 DPI, a 1.3 mm tumor was observed with approximately 5% loss of body weight the following day (D). At 75 DPI, a 5 mm tumor was observed, with approximately 15% loss of body weight and other symptoms signaling clinical endpoint (E). A zoom image of this time point is shown (F). Tumor growth was slowed upon treatment with 10 mg/kg/day etomoxir in mouse 078 (G-K). This animal first manifested tumor by MR at 95 DPI; at 97 DPI, this animal lost 15% body weight and reached clinical endpoint. A zoom image of this animal's brain at 75 DPI is shown to compare with the vehicle-treated animal at the same time point (L).