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. 2016 Jul 10;19(1):22–30. doi: 10.1093/neuonc/now139

Fig. 3.

Fig. 3

Upregulation of Ccl2 by activated TrkB is mediated by STAT3 signaling. (A) Supernatants from the indicated cells grown in serum-free medium for 1 day were collected and analyzed using a murine cytokine array. The bar graph represents spot intensity. Data from vector control cells were set as 1.0. (B) Quantitative PCR of mRNA expression levels of Ccl2 in NTRK2-TEL cells compared with those from control vector cells, which were set to 1.0. **P < .01. (C) CCL2 protein levels were measured by ELISA. Vector, NTRK2-TEL, and QKI-NTRK2 cells were serum starved for 2 days and supernatants were collected for analysis by ELISA. **P < .01. (D) Quantitative PCR of mRNA expression levels of Ccl2 in shStat3 cells compared with levels in shScr control cells, which were set to 1.0. **P < .01.