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Contrast-enhanced T1-weighted digital subtraction maps. In order to increase lesion conspicuity and increase automation in tumor segmentation, (A) pre- and (B) postcontrast T1-weighted images were intensity normalized, coregistered, and subtracted voxel-by-voxel, highlighting only areas of increased signal intensity following contrast administration. The resulting T1 subtraction maps (C) were used to quantify enhancing lesion volume, which also included areas of central necrosis.
