Fig. 4.
Bmax for [3H]nisoxetine binding to SERT in SERT+/+ and SERT+/− mice aged P21, P28, and P90. Bmax values from P21, P28, and P90 SERT+/+, SERT+/−, and SERT−/− mice in the CA1 region (A), CA2 region (B), CA3 region (C), dentate gyrus (D), and locus coeruleus (E) were determined from one-site curve fits as described in the Materials and Methods. Data are means ± S.E.M. *P < 0.05 (significant difference from SERT genotype–matched P90, Dunnett post hoc multiple comparisons test after a two-factor ANOVA for age and SERT genotype). Data are means ± S.E.M. pooled from male and female mice. Sample sizes of mice per group were as follows: SERT+/+, n = 5–9 (4 males and 3–5 females, pooled); SERT+/−, n = 6–10 (3–5 males and 2–4 females, pooled); and SERT−/−, n = 4–7 (2–4 males and 2–4 females, pooled).