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(A) Correlation between POR protein levels (pmol/mg) and CYP2A6 activity (cotinine formation from nicotine, nmol/min per milligram). Values for r and P determined on the basis of Spearman correlations. (B–D) Association between POR SNP rs17148944 and (B) POR mRNA expression (FPKM values), (C) POR protein levels (pmol/mg), and (D) CYP2A6 activity (cotinine formation from nicotine, nmol/min per milligram). P values for B–D all >0.1, on the basis of Kruskal-Wallis tests.
