Effect of cocaine, ethylone, and METH on [3H]neurotransmitter release. hDAT (A), hSERT (C), and hNET (E) show the time courses of the average fractional release (mean ± S.E.M.) in the presence of buffer, cocaine (10 µM), ethylone (30 µM), or the maximally effective concentrations of METH (10 µM, hDAT; 100–300 µM, hSERT; 1 µM, hNET). hDAT (B), hSERT (D), and hNET (F) show the average AUC for fractional release for each condition tested. N = 3–6. **P < 0.01 and ****P < 0.0001 compared with basal release, one-way ANOVA followed by Dunnett’s multiple comparison test.