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. 2017 Jan;360(1):33–47. doi: 10.1124/jpet.116.236349

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Fig. 6. — Correlation between the ratio of affinity for the transporter (K_i) and the potency for inhibition of uptake (IC₅₀) to the maximal releasing efficacy of the test compounds. hDAT (A), hSERT (B), and hNET (C). The data were fit to a hyperbolic equation. Values for nonparametric Spearman’s correlation (r) and significance are as follows: DAT r = 0.84, P < 0.0001 (A); SERT r = 0.73, P < 0.0001 (B); and NET r = 0.78, P < 0.0001 (C). All of the correlations are highly significant. Amph, (+)-amphetamine.