. 2016 Nov;12(11):668–679.

Table 3.

Results of Murine Colitis Models Treated With Cannabinoids

Study	Results
Borrelli et al²⁹	In DNBS-induced colitis, cannabidiol reduced colon injury, decreased expression of inflammatory markers and inducible nitric oxide synthase, and decreased reactive oxygen species production.
Jamontt et al³⁰	TNBS-induced colitis treated with THC, cannabidiol, THC combined with cannabidiol, and sulphasalazine compared with controls showed decreased inflammation and functional disturbances after treatment with THC and cannabidiol. THC alone or with cannabidiol improved the function of cholinergic motor neurons, results not seen with sulphasalazine use.
Cluny et al³¹	A peripherally restricted CB1/CB2 agonist was ineffective in dextran sodium sulfate—induced colitis and did not significantly reduce colitis in a TNBS-colitis model.
D’Argenio et al³²	Use of VDM11, an inhibitor of fatty acid amide hydrolase, increases anandamide tone, which improves TNBS- and DNBS-induced rat colitis.

CB1, cannabinoid 1 receptor; CB2, cannabinoid 2 receptor; DNBS, dinitrobenzene sulfonic acid; THC, tetrahydrocannabinol; TNBS, trinitrobenzene sulfonic acid; VDM11, N-(-4-hydroxy-2-methylphenyl) arachidonoyl amide.