Table 4.

Therapy Studies Evaluating Clinical Response in Patients With IBD

Study	Study Design	Subjects	Treatment	Outcomes
Naftali et al33	Retrospective, observational	30 patients with Crohn’s disease	Retrospective inhalational or oral cannabis use	Significant clinical response but need for other drugs and surgery with cannabis
Lahat et al34	Prospective, observational without controls	13 patients with IBD	50 g of cannabis cigarette per month (3 months total)	Significant improvement in quality of life, disease activity, and weight gain
Naftali et al35	Prospective, randomized, double-blind, placebo-controlled	21 patients with Crohn’s disease	Cannabis sativa cigarette (23% THC, 0.5% cannabidiol)	Significant clinical response with cannabis but no objective decrease in inflammation

IBD, inflammatory bowel disease; THC, tetrahydrocannabinol.