Table 2.
Evaluation and Identification of Cancer Predisposition Syndromes in Pancreatic Cancer Patients.
Syndrome | # of patients who completed evaluation | Mutation prevalence |
---|---|---|
Overall | 159 | 24 (15.1%) |
HBOC (BRCA1, BRCA2) |
151 | 17 (11.3%) 4 BRCA1 mutations; 13 BRCA2 mutations |
Lynch syndrome (MLH1, MSH2, MSH6, PMS2) |
36 | 4 (11.1%) 1 MLH1 mutation; 2 MSH2 mutations; 1 MSH6 mutation |
PALB2 | 48 | 1 (2.1%) |
FAMMM (p16) | 17 | 2 (11.8%) |
HBOC = Hereditary Breast and Ovarian Cancer syndrome;
FAMMM = Familial Atypical Multiple Mole Melanoma syndrome