Table 3.
Germline Mutation Prevalence in Pancreatic Cancer Patient Cohorts.
Patient population | N | Number of patients tested | Pathogenic mutation identified | BRCA1 mutation | BRCA2 mutation | Other Gene |
---|---|---|---|---|---|---|
Ashkenazi Jewish | 98 | 96 | 15 (15.6%) | 2 | 11 | 2 |
Non-Ashkenazi Jewish | 77 | 63 | 9 (14.3%) | 2 | 2 | 5 |
Early-onset (age ≤50) | 26 | 21 | 6 (28.6%) | 2 | 0 | 4 |
Late-onset (age ≥70) | 51 | 46 | 3 (6.5%) | 2 | 1 | 0 |
Familial Pancreatic | 40 | 34 | 2 (5.9%) | 1 | 1 | 0 |