. Author manuscript; available in PMC: 2016 Dec 28.

Published in final edited form as: Cancer. 2015 Oct 6;121(24):4382–4388. doi: 10.1002/cncr.29664

Table 4.

Prevalence of BRCA1/BRCA2 Mutation by Ethnicity and Family Cancer History.

Patient & Family History	Number of Patients who underwent BRCA testing	BRCA1/BRCA2 Mutation Prevalence	Gene/Mutation
Ashkenazi Jewish ancestry	95	13 (13.7%)	1 BRCA1185delAG 1 BRCA15382insC 11 BRCA2*6174delT
≥2 FDR or SDR with BRCA-associated cancer^*	30	5 (16.7%)	5 BRCA2*6174delT
1 FDR or SDR with a BRCA-associated cancer^*	38	6 (15.8%)	1 BRCA1185delAG 1 BRCA15382insC 4 BRCA2*6174delT
No family history	27	2 (7.4%)	2 BRCA2*6174delT
Non-Ashkenazi ancestry	56	4 (7.1%)	2 BRCA1 2 BRCA2
≥2 FDR or SDR with BRCA-associated cancer^*	26	2 (7.7%)	1 BRCA1 1 BRCA2
1 FDR or SDR with a BRCA-associated cancer^*	18	2 (11.1%)	1 BRCA1 1 BRCA2
No family history	12	0	N/A

FDR = first degree relative; SDR = second degree relative

BRCA-associated cancer includes breast, ovarian, pancreas