Fig. 1.
The SIRT2 inhibitor AGK2 is neuroprotective in males but not females. A) Representative images of H&E stained sections of CA1 pyramidal neurons from male and female vehicle or AGK2 treated mice subjected to 8 min CA and recovered for 3 days. Injured neurons were identified by pyknotic nuclei and hypereosinophilic cytoplasm. B) Injured and non-injured cells were quantified and are presented as % ischemic neurons (mean ± SEM). AGK2 administration reduced % ischemic neurons in males but not females (* indicates p < 0.05).