Skip to main content
. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Proteins. 2016 Nov 29;85(1):117–124. doi: 10.1002/prot.25204

Figure 1.

Figure 1

Dimeric arrangement of heart form and a comparison of the structures of the human and bovine orthologues. (A) Head-to-head homodimer arrangement of the human PFKFB2. Shown in gray is a complete monomer, while the red and blue colors depict the 2-Kase and 2-Pase domains, respectively. Ligands are colored by element and are shown in stick form. (B) Superimposed C-alpha traces of bovine (blue) and human (light gray) kinase and phosphatase domains. The phosphatase domains contain Fru-6-P from the bovine orthologue in the F-2,6-P2 binding site. The kinase domains with ADP and Citrate from the bovine orthologue in the ATP and F6P binding sites, respectively.