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Methyl-directed repair in E. coli extract supports bidirectional excision.
Incubation of 5′ (left) or 3′ (right) hemimethylated G-T heteroduplex DNA in E. coli extract in the presence if dideoxynucleoside-5′-triphosphates results in production of a single-strand gap that spans the shorter path between the two DNA sites (18,19).
