Table 3.
Genetic modeling of BPD-associated pulmonary hypertension: rs480414 SNP in DDAH1.
| Genetic model | BPD alone, n (%) | BPD+PH, n (%) | p-value1 | OR (95% CI)2 | p-value2 |
|---|---|---|---|---|---|
| rs233115 | |||||
| Recessive | 34 (46.6) | 8 (32.0) | 0.20 | 0.54 (0.21–1.41) | 0.20 |
| Dominant | 39 (53.4) | 17 (68.0) | 0.20 | 1.85 (0.71–4.83) | 0.20 |
| Additive | 8 (11.0) | 4 (16.0) | 0.32 | 1.60 (0.83–3.09) | 0.16 |
| rs233130 | |||||
| Recessive | 34 (46.6) | 8 (32.0) | 0.20 | 0.54 (0.21–1.41) | 0.20 |
| Dominant | 39 (53.4) | 17 (68.0) | 0.20 | 1.85 (0.71–4.83) | 0.20 |
| Additive | 8 (11.0) | 4 (16.0) | 0.32 | 1.60 (0.83–3.09) | 0.16 |
| rs480414 | |||||
| Recessive | 34 (46.6) | 17 (68.0) | 0.06 | 2.44 (0.94–6.35) | 0.06 |
| Dominant | 39 (53.4) | 8 (32.0) | 0.06 | 0.41 (0.16–1.07) | 0.06 |
| Additive | 11 (15.1) | 1 (4.0) | 0.06 | 0.39 (0.18–0.88) | 0.01 |
| rs1403955 | |||||
| Recessive | 29 (39.7) | 5 (20.0) | 0.07 | 0.38 (0.13–1.12) | 0.06 |
| Dominant | 44 (60.3) | 20 (80.0) | 0.07 | 2.64 (0.89–7.81) | 0.06 |
| Additive | 12 (16.4) | 5 (20.0) | 0.37 | 1.47 (0.77–2.80) | 0.24 |
| rs1498373 | |||||
| Recessive | 42 (57.5) | 11 (44.0) | 0.24 | 0.58 (0.23–1.45) | 0.24 |
| Dominant | 31 (42.5) | 14 (56.0) | 0.24 | 1.72 (0.69–4.31) | 0.24 |
| Additive | 6 (8.2) | 4 (16.0) | 0.49 | 1.45 (0.75–2.79) | 0.27 |
| rs2177461 | |||||
| Recessive | 32 (43.8) | 7 (28.0) | 0.16 | 0.50 (0.19–1.34) | 0.16 |
| Dominant | 41 (56.2) | 18 (72.0) | 0.16 | 2.01 (0.75–5.39) | 0.16 |
| Additive | 7 (9.6) | 4 (16.0) | 0.25 | 1.76 (0.88–3.50) | 0.11 |
| rs12132677 | |||||
| Recessive | 35 (48.0) | 9 (36.0) | 0.30 | 0.61 (0.24–1.56) | 0.30 |
| Dominant | 38 (52.1) | 16 (64.0) | 0.30 | 0.54 (0.21–1.41) | 0.20 |
| Additive | 9 (12.3) | 4 (16.0) | 0.51 | 1.41 (0.74–2.68) | 0.30 |
1
Genotype frequencies analyzed with chi-square test.
2
Univariate logistic regression.
SNP, single nucleotide polymorphism; BPD, bronchopulmonary dysplasia; rs, NCBI dbSNP number; DDAH, dimethylarginine dimethylaminohydrolase.