Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 26;26(12):4405–4415. doi: 10.1093/cercor/bhw268

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 6. — Blocking ipsilateral S1 reduces responses to both ipsi- and contralateral whisker stimulation. (A) Diagram of the experimental configuration and main synaptic pathways; arrows in red show the synaptic outputs blocked by TTX injection to ipsilateral S1. Unblocked regions and pathways (green) and recording electrodes in dorsolateral striatum and S1 of both cortical hemispheres. (B) Example of a TTX (10 µM) and neurobiotin (0.4%) injection-site in ipsilateral S1. (C) Waveform average (>40 repetitions) of a whole-cell recorded MSN with simultaneous cortical LFP recordings in response to contra-, ipsi-, and bilateral whisker deflection before and after injection of TTX 10 µM in ipsilateral S1. The gray bar represents the air-puff whisker deflection. (D) Absolute response amplitude to contra-, ipsi-, and bilateral whisker deflection before and after TTX application in ipsilateral S1 (n = 6 animals). (E) Normalized amplitude change in striatal whole-cell recordings. The normalization was done with respect to the control condition for each neuron and type of stimulation (n = 6). (F) Normalized amplitude with respect to the control condition for each LFP recording in the right and left cortical hemisphere and type of stimulation (n = 6). All responses are measured during down states. Asterisks *, **, *** represent P values <0.05, <0.01, <0.001, respectively.