Figure 1.

Schematic of the inverse parameter estimation procedure. The volumetric MR data from the initial and post one NAT cycle is converted to estimate tumor cellularity at each time point. Given an initial guess of the model parameters, the model is initialized by the tumor cellularity at the initial time point and used to generate an estimate of the tumor cellularity at the post one NAT cycle time point. The model estimate is compared to the data observation for the post one NAT cycle cellularity and parameters are iteratively refined until convergence below a preset tolerance to yield an initial estimate of the parameters.