Table 2.

Itch secondary to skin diseases

Study	Country	Design	N of subjects	Drugs	Via	Duration	Instrument	Type of itch	Results
Greene et al., 1985	USA	Longitudinal, controlled, double-blind, randomized	50	Doxepin 10mg or diphenhydramine 25mg 3x/day	Oral	31 days	McNemar test	Chronic idiopathic urticaria	Itch decreased with doxepin according to the instrument used
Goldsobel et al., 1986	USA	Longitudinal, placebo-controlled, double-blind, randomized	16	Doxepin 25mg Placebo 3x/day	Oral	8 weeks	Clinical evaluation	Chronic idiopathic urticaria	Itch decrease with doxepin
Panahi Y et al., 2011	Iran	Prospective, randomized, single-blind	75	Doxepin cream 5% or betamethasone cream	Topic	6 weeks	VAS Itch score DLQI	Lesion due to mustard gas	Significant decrease of pruritus with both topical drugs
Groene D et al., 2001	Germany	Longitudinal, placebo-control, randomized, crossover	11	Doxepin cream 5%; Wolff basis cream (placebo)	Topic	4 days	SDS (self-rating depression scale)	Atopic eczema	No significant antipruritic action of doxepin compared with basis cream

Legend: WO- washout; VAS: Visual Analogue Scale