Figure 3.

GLP-1 enhances the effect of MSCs on preserving islet β cell function in NOD mice. Following treatment with MSCs and GLP-1 or MSCs alone, the levels of fasting insulin in individual mice at the indicated time points post treatment were measured and the content of insulin in the pancreatic islets was determined by immunohistochemistry. Data are representative images (magnification × 400) or expressed as the mean ± SEM of each group of mice (n = 6 per group per time point) from three separate experiments. (A) Fasting plasma insulin levels. (B) Immunohistochemistry analysis of insulin content in the pancreatic islets. (C) Quantitative analysis of insulin levels. *P < 0.05 versus diabetic controls. †P < 0.05 versus mice treated with MSCs alone.