Table 1. Definition of Treatment Outcomes.

Outcomes at the end of treatment	Definition
Failure	AFB microscopies or cultures positive at five months or later during treatment.
Cure	Treatment completed with disappearance of signs and symptoms and two or more AFB smears or cultures with negative results at the end of therapy.
Treatment completion	Completion of treatment without meeting the criteria to be classified as a cure or a failure.
Death during treatment	Death due to any cause during therapy.[18]
Default	Interruption of treatment for two consecutive months or more.[18]
Transfer out	Patient transferred to another institution outside of the study region.
Outcomes after treatment was completed
Recurrence	A second or subsequent episode of TB confirmed by AFB smear or culture in a patient with a history of prior treatment.a
Relapse	TB disease confirmed by AFB smear or culture that occurred after a patient was considered to have completed treatment or to have been cured.[18]
Reinfections	Subsequent TB episodes with the same genotype: six or more IS6110 bands in an identical pattern, or < 6 bands with identical IS6110 RFLP patterns and a spoligotype with the same spacer oligonucleotides.
Deaths after TB treatment was completed
Death due to TB	Deaths were attributed to TB based on two of the following: death certificate with TB as the main cause of death; interview with a close caregiver who identified TB as a probable cause of death; or positive AFB smear or culture at the time of death.
Death due to any cause	Death without specifying cause

^a Relapse patients are included within recurrent TB.