Table 3. Correlations between clinical, histological and molecular data and OS: univariate analysis.
| Total cohort | Oligodendrogliomas | Astrocytomas | |||||
|---|---|---|---|---|---|---|---|
| Hazard ratio(95% CI) | p-value | Hazard ratio(95% CI) | p-value | Hazard ratio(95% CI) | p-value | ||
| Histological grade | Low / High grade | 0.43 | 0,03 | 0,69 | NS | 0 | 0,009 |
| Recurrence | No / Yes | 2.95 | 0,02 | 29,35 | 0,00002 | 0,99 | NS |
| Age at diagnosis | < 50 / ≥ 50 years | 1.26 | NS | 2,02 | NS | 0,6 | NS |
| Sex | Male / Female | 0.95 | NS | 0,71 | NS | 3,95 | NS |
| Localization | Frontal / Other | 2.08 | NS | 2 | NS | 2,7 | NS |
| Postoperative treatment | No / Yes | 0.43 | NS | 0,36 | 0,05 | - | - |
| MVP | No / Yes | 1.85 | NS | 1,45 | NS | 0.7 | 0,05 |
| Calcifications | No / Yes | 0.33 | 0,01 | 0,16 | 0,002 | 1,04 | NS |
| Mitoses /10 HPF | < 5 / ≥ 5 | 1.93 | NS | 1,88 | NS | 2,04 | NS |
| Mib1 | < 12 / ≥ 12 | 1.3 | NS | 1,15 | NS | 1,53 | NS |
| INA | Negative / Positive | 1.22 | NS | 3,96 | NS | - | - |
| IDH 132H | Negative / Positive | 1.89 | NS | - | - | 9,48 | 0,02 |
| ATRX | Negative / Positive | 0.42 | NS | - | - | 0,6 | NS |
| Chr 1p | deletion / other | 2.19 | NS | - | - | 2 | NS |
| Chr 9p | deletion / other | 0.25 | 0,0007 | 0,34 | 0,03 | 0 | 0,001 |
| Chr 10q | deletion / other | 0.13 | 0,003 | - | - | 0,16 | 0,04 |
| Chr arm alteration (Mean) | ≤ 2 / > 2 | 1.18 | NS | 1,29 | NS | 0,87 | NS |
| Chr arm deletion (Mean) | ≤ 2 / > 2 | 2.09 | NS | 2,98 | 0,03 | - | - |
NS: Not significant,—: Not applicable