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. Author manuscript; available in PMC: 2016 Dec 28.
Published in final edited form as: Exp Neurol. 2015 Mar 24;269:56–66. doi: 10.1016/j.expneurol.2015.03.015

Fig. 4. Post-injury administration of PFT-α or PFT-α (O) at 5 h after TBI significantly decreased p53 and Annexin V positive neurons in the cortical contusion region at 8 h.

Fig. 4

(A) Co-immunohistochemistry of p53 and NeuN in cortical brain tissue. (C) Co-immunohistochemistry of Annexin V and NeuN in cortical brain tissue. p53 or annexin V immunoreactivity is shown in green, and NeuN (a marker for neurons) is shown in red. Yellow labelling indicates colocalization. (B, D) There was a significant decrease in the number of p53 and Annexin V positive neurons in TBI + PFT-α and TBI + PFT-α (O) group, respectively. Data represent the mean ±SEM. **p<0.01; ***p<0.001 versus the sham group; ##p<0.001; ###p<0.001 versus the TBI + veh group; ++p<0.01; +++p<0.001 versus the TBI + PFT-α group. Scale bar=100 μm. (n=5 for each group).

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