Table 4. Associations between Inflammatory Markers Associated with Oxidative Stress and Echocardiographic Parameters.
Parameter | Correlation coefficient | ||||||
---|---|---|---|---|---|---|---|
IL-1β | IL-6 | IL-8 | MCP-1 | TNF-α | MMP-2 | MMP-9 | |
Structural abnormality | |||||||
LVEF, % | –0.162 | 0.023 | –0.021 | 0.442 | 0.309 | 0.200 | 0.459 |
LVEDD, mm | 0.343 | 0.032 | 0.177 | 0.290 | 0.035 | 0.095 | –0.313 |
LVESD, mm | 0.411 | 0.106 | 0.196 | –0.083 | –0.192 | –0.099 | –0.622a |
IVSd, mm | 0.424 | 0.276 | –0.060 | –0.206 | –0.008 | –0.086 | 0.538a |
PWd, mm | 0.099 | –0.054 | –0.315 | –0.242 | –0.205 | –0.145 | –0.061 |
LV mass, g | 0.386 | 0.478 | –0.040 | 0.186 | 0.246 | 0.206 | 0.553a |
LVMI, g/m2 | 0.487 | 0.444 | –0.101 | –0.043 | 0.032 | –0.037 | 0.329 |
LAVI, mL/m2 | 0.694a | 0.060 | –0.001 | –0.165 | 0.077 | –0.115 | 0.040 |
RWT | –0.402 | 0.127 | 0.218 | 0.164 | 0.223 | 0.114 | 0.182 |
Function | |||||||
E velocity, m/sec | 0.587 | 0.680a | 0.071 | –0.214 | –0.086 | –0.160 | 0.265 |
A velocity, m/sec | –0.172 | 0.401 | 0.425 | 0.615a | 0.819a | 0.751a | 0.502 |
E/A ratio | 0.52 | 0.402 | 0.029 | –0.472 | –0.436 | –0.472 | –0.133 |
Deceleration time, msec | 0.002 | –0.100 | 0.053 | 0.446 | 0.120 | 0.267 | –0.131 |
E’, m/sec | 0.335 | 0.127 | –0.354 | –0.517a | –0.422 | –0.371 | –0.046 |
E/E’ ratio | 0.300 | 0.418 | 0.512 | 0.179 | 0.297 | 0.505 | –0.031 |
Spearman partial correlation adjusted for age and sex was used to examine the relationships between inflammatory markers associated with oxidative stress and echocardiographic parameters.
IL, interleukin; MCP, monocyte chemoattractant protein; TNF-α, tumor necrosis factor α; MMP, matrix metalloproteinase; LVEF, left ventricular ejection fraction; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; IVSd, interventricular septum diameter; PWd, posterior wall diameter; LV, left ventricular; LVMI, left ventricular mass index; LAVI, left atrial volume index; RWT, relative wall thickness.
aP<0.05, after adjustment for age and sex.