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. Author manuscript; available in PMC: 2018 Jan 2.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Dec 2;56(1):193–197. doi: 10.1002/anie.201609269

Figure 1.

Figure 1

Structures of G4 and G5 dendrimers and pharmacological testing. a) Cartoon representations of G4 and G5 dendrimers with surface hydroxyl functionality; b,) GABA-A antagonism of the dendrimers assessed by dose-dependent blockade of evoked GABAergic inputs onto layer 2/3 pyramidal cells. The IC50 for G4-GABA was 0.52 mM and G5-GABA 5.4 mM. No convergence was found for fitting the G4 dendrimer antagonism, suggesting this compound was not antagonistic. AMPA-R, NMDA-R were blocked during these recordings.