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. Author manuscript; available in PMC: 2018 Jan 2.
Published in final edited form as: Angew Chem Int Ed Engl. 2016 Dec 2;56(1):193–197. doi: 10.1002/anie.201609269

Figure 2.

Figure 2

Structure of G5-DEAC450-GABA and pharmacological testing. GABA-A antagonism of G5-DEAC450-GABA was assessed by dose-dependent blockade of evoked GABAergic inputs onto layer 2/3 pyramidal cells by increasing the concentration of caged compound applied to brain slices (Asp- and PEG-DEAC450-GABA are adapted and drawn with permission from[18], copyright 2014 American Chemical Society). AMPA-R and NMDA-R were blocked during these recordings.