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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Ageing Res Rev. 2016 Jun 29;33:18–29. doi: 10.1016/j.arr.2016.06.007

Figure 2. Expression of progerin alters nuclear organization and genome stability.

Figure 2

Cells from HGPS patients are characterized by a series of alterations including reduced expression of extracellular matrix (ECM) components, nuclear envelope blebs, clustering of nuclear pore complexes (NPC), loss of peripheral heterochromatin, and reorganized microtubules. Progerin expression also affects dynamics of nuclear envelope transmembrane proteins (NETs), including emerin, and their interactions with chromatin-associated proteins, such as BAF, transcription factors (TF) and chromatin modifiers. HGPS cells have higher levels of reactive oxygen species (ROS) and DNA damage, whereas LAP2α is downregulated.