. Author manuscript; available in PMC: 2018 Jan 1.

Published in final edited form as: Stem Cells. 2016 Nov 10;35(1):35–41. doi: 10.1002/stem.2507

Table 2. Summary of preferred conditions to establish naïve hESC from established primed lines, without transgenes.

Reference by first author	Inhibitors used	growth factors
Chan (36)	2i, dorsomorphin	hLIF
Gafni (37)	2i, JNKi, p38^MAPKi	hLIF, FGF2, TGFβ1
Ware (23)	2i	FGF2 (HDACi pretreatment^*)
Theunissen (26)	2i^*, BRAFi, SRCi, ROCKi	hLIF, FGF2, Activin A
Theunissen (31)	2i (or without GSK3i) BRAFi, SRCi, ROCKi	hLIF, Activin A
Duggal (38)	2i	ascorbic acid, forskolin, hLIF, FGF2
Carter (39)	(ROCKi)	NME7_AB,

HDACi – sodium butyrate + vorinostat/SAHA