Table 4. Differing characteristics between the naïve and primed states from combined literature.
Naïve | Primed | |
---|---|---|
Morphology | mounded | flat |
Single-cell passage (w/o ROCKi) | yes | no |
Relative gene expression: | ||
TBX3 | high | low |
DNMT3L | high | low |
IL6ST (GP130) | high | low |
DNMT3B | low | high |
CD24 | low | high |
Transposable elements | high | low |
HERVK | high | low |
OCT4 enhancer use | distal | proximal |
Relative H3K27me3 marks | low | high |
X-activation | XaXa | XaXi |
Metabolism | Ox-Phos | Glycolytic |